Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria
Abstract Background Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered.This could lead to imprecise estimates of the target PK parameters, a