OPTIMAL DESIGNS FOR POPULATION PHARMACOKINETIC STUDIES OF ORAL ARTESUNATE IN PATIENTS WITH UNCOMPLICATED FALCIPARUM MALARIA

Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

Abstract Background Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered.This could lead to imprecise estimates of the target PK parameters, a

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Design and Performance Evaluation of a Cherry Tomato Calyx Remover

A prototype for the remover of cherry tomato calyxes was designed and manufactured.The tap remover was designed and manufactured considering the conveyor transport speed, brush length nyx 22 brush and clearance, and diameter.These were adjusted in three levels to determine the optimal design factor.Performance tests were conducted using Icon 513, a

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